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Article

Awakening guardian angels: drugging the p53 pathway.

Nature reviews. Cancer - 1 Dec 2009

Brown Christopher J, Lain Sonia, Verma Chandra S, Fersht Alan R, Lane David P

Abstract excerpt

Currently, around 11 million people are living with a tumour that contains an inactivating mutation of TP53 (the human gene that encodes p53) and another 11 million have tumours in which the p53 pathway is partially abrogated through the inactivation of other signalling or effector components. The p53 pathway is therefore a prime target for new cancer drug development, and several original approaches to drug...

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Signal Transduction
Proto-Oncogene Proteins c-mdm2
Antineoplastic Agents
Drug Delivery Systems
Drug Design

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

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PMID: 19935675
DOI: 10.1038/nrc2763

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MDM2

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