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Article

Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain.

Archives of virology - 1 Jan 2009

Weng Leiyun, Du Jiamu, Zhou Jingling, Ding Jianping, Wakita Takaji, Kohara Michinori, Toyoda Tetsuya

Abstract excerpt

Hepatitis C virus (HCV) JFH1 efficiently replicates and produces infectious virus particles in cultured cells. We compared polymerase activity between JFH1 and 1b strains in vitro. The RNA polymerase activity of 1b was 6.4% of that of JFH1. In order to study the mechanism and identify domains res...

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Source

Identifiers

PMID: 19340394
DOI: 10.1007/s00705-009-0366-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19340394-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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