Article
Fog2 excision in mice leads to premature mammary gland involution and reduced Esr1 gene expression.
Oncogene - 9 Aug 2007
Manuylov N L, Smagulova F O, Tevosian S G
Abstract excerpt
The critical role for GATA family proteins in maintaining the normal (non-transformed) cell state is corroborated by the recent findings of mutations or methylation in GATA genes both in primary cancers and tumor lines including breast. Previously, microarray profiling studies determined that the highest expression of both GATA3 and ESR1 (estrogen receptor alpha) is seen in tumors associated with the most...
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