Article
Motor coordination deficits in Alpk1 mutant mice with the inserted piggyBac transposon.
BMC neuroscience - 5 Jan 2011
Chen Muyun, Xu Rener
Abstract excerpt
BACKGROUND: ALPK1 (α-kinase 1) is a member of an unconventional alpha-kinase family, and its biological function remains largely unknown. Here we report the phenotypic characterization of one mutant line, in which the piggyBac (PB) transposon is inserted into the Alpk1 gene. RESULTS: The piggyBac(PB) insertion site in mutants was mapped to the first intron of the Alpk1 gene, resulting in the effective disruption...
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