Back to search

Article

A cost effective high-resolution climbing assay applied to <i>Drosophila</i> Parkinson’s and proprioception mutants reveal novel behavioural phenotypes

2018-09-25

Abstract excerpt

Severe locomotor impairment is a common phenotype of neurodegenerative disorders such as Parkinson’s disease (PD). Drosophila models of PD, studied from more than a decade, have helped in understanding the interaction between various genetic factors, such as parkin and PINK1, in this disease. To characterize locomotor behavioural phenotypes for these genes, fly climbing assays have been widely used. While these...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b306d24f-d802-51b1-8348-d4a6a6a5331b
DOI
10.1101/426544
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A cost effective high-resolution climbing assay applied to <i>Drosophila</i> Parkinson’s and proprioception mutants reveal novel behavioural phenotypesDOI 10.1101/426544
A locomotor assay reveals deficits in heterozygous Parkinson’s disease model and proprioceptive mutants in adult DrosophilaSemantic proximity
Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative DisordersSemantic proximity
High-resolution, high-throughput analysis of <i>Drosophila</i> geotactic behaviorSemantic proximity
Altered reactivity to threatening stimuli in <i>Drosophila</i> models of Parkinson’s disease, revealed by a trial-based assaySemantic proximity
Quantification of gait parameters in freely walking wild type and sensory deprived Drosophila melanogaster.Semantic proximity
An Automated Rapid Iterative Negative Geotaxis Assay for Analyzing Adult Climbing Behavior in a Drosophila Model of NeurodegenerationSemantic proximity
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.Semantic proximity
Comparative Analysis of Experimental Methods to Quantify Animal Activity in Caenorhabditis elegans Models of Mitochondrial Disease.Semantic proximity
An automated climbing apparatus to measure chemotherapy-induced neurotoxicity in<i>Drosophila melanogaster</i>Semantic proximity
The burrowing behavior of the nematode <i>Caenorhabditis elegans</i>: a new assay for the study of neuromuscular disordersSemantic proximity
Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining.Semantic proximity
An optogenetic assay of <i>Drosophila</i> larval motor neuron performance <i>in vivo</i>Semantic proximity
Select a neighboring publication to make it the new centre.