Article
Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice.
Learning & memory (Cold Spring Harbor, N.Y.) - 1 Jan 2000
Paylor R, Hirotsune S, Gambello M J, Yuva-Paylor L, Crawley J N, Wynshaw-Boris A
Abstract excerpt
Heterozygous mutation or deletion of Pafab1b1 (LIS1) in humans is associated with syndromes with type 1 lissencephaly, a severe brain developmental disorder resulting from abnormal neuronal migration. We have created Lis1 heterozygous mutant mice by gene targeting. Heterozygous mutant mice are viable and fertile, but display global organizational brain defects as a result of impaired neuronal migration. To assess...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.