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Article

Stress-induced evolution of Escherichia coli points to original concepts in respiratory cofactor selectivity.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2011

Auriol Clément, Bestel-Corre Gwénaëlle, Claude Jean-Baptiste, Soucaille Philippe, Meynial-Salles Isabelle

Abstract excerpt

Bacterial metabolism is characterized by a remarkable capacity to rapidly adapt to environmental changes. We restructured the central metabolic network in Escherichia coli to force a higher production of NADPH, and then grew this strain in conditions favoring adaptive evolution. A six-fold increase in growth capacity was attained that could be attributed in multiple clones, after whole genome mutation mapping, to...

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Identifiers

PMID: 21205901
DOI: 10.1073/pnas.1010431108
PMCID: PMC3029715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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