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Article

Validation of isoleucine utilization targets in Plasmodium falciparum.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2011

Istvan Eva S, Dharia Neekesh V, Bopp Selina E, Gluzman Ilya, Winzeler Elizabeth A, Goldberg Daniel E

Abstract excerpt

Intraerythrocytic malaria parasites can obtain nearly their entire amino acid requirement by degrading host cell hemoglobin. The sole exception is isoleucine, which is not present in adult human hemoglobin and must be obtained exogenously. We evaluated two compounds for their potential to interfere with isoleucine utilization. Mupirocin, a clinically used antibacterial, kills Plasmodium falciparum parasites at...

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Identifiers

PMID: 21205898
DOI: 10.1073/pnas.1011560108
PMCID: PMC3029723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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