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Article

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state.

Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2012

Babbitt Shalon E, Altenhofen Lindsey, Cobbold Simon A, Istvan Eva S, Fennell Clare, Doerig Christian, Llinás Manuel, Goldberg Daniel E

Abstract excerpt

The human malaria parasite Plasmodium falciparum is auxotrophic for most amino acids. Its amino acid needs are met largely through the degradation of host erythrocyte hemoglobin; however the parasite must acquire isoleucine exogenously, because this amino acid is not present in adult human hemoglobin. We report that when isoleucine is withdrawn from the culture medium of intraerythrocytic P. falciparum, the...

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Identifiers

PMID: 23112171
DOI: 10.1073/pnas.1209823109
PMCID: PMC3511138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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