Article
A founder BRCA2 mutation in non-Afrikaner breast cancer patients of the Western Cape of South Africa.
Clinical genetics - 1 Feb 2012
van der Merwe N C, Hamel N, Schneider S-R, Apffelstaedt J P, Wijnen J T, Foulkes W D
Abstract excerpt
Founder mutations in BRCA1 and BRCA2 have been reported in many different populations. We studied 105 Coloured and 16 Black Xhosa women residing in the Western Cape of South Africa diagnosed with breast cancer. We screened these patients using our standard panel of six previously reported SA Afrikaner and Ashkenazi Jewish BRCA1/2 mutations and identified only two Afrikaner mutations. Further screening by the...
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