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The frequency of founder mutations in theBRCA1,BRCA2, andAPC genes in australian Ashkenazi Jews

1 Jan 2001

Abstract excerpt

BACKGROUND: Several studies have shown that Ashkenazi Jews in the United States and Israel have a high prevalence of the founder mutations BRCA1 185delAG, BRCA1 5382insC, BRCA2 6174delT, and APC I1307K at frequencies of 1.0--1.1%, 0.2--0.3%, 0.6--1.4%, and 6.1--7.0%, respectively. The objective of this study was to compare the prevalence of these alleles in the Australian Jewish population with that of U.S. Jews....

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PMID: 11466700
DOI: 10.1002/1097-0142(20010715)92:2<440::aid-cncr1340>3.0.co;2-o

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