Article
BRCA1 point mutations in premenopausal breast cancer patients from Central Sudan.
Familial cancer - 1 Sept 2014
Biunno Ida, Aceto Gitana, Awadelkarim Khalid Dafaallah, Morgano Annalisa, Elhaj Ahmed, Eltayeb Elgaylani Abdalla, Abuidris Dafalla Omer, Elwali Nasr Eldin, Spinelli Chiara, De Blasio Pasquale, Rovida Ermanna, Mariani-Costantini Renato
Abstract excerpt
Premenopausal breast cancer (BC) is one of the most common cancers of women in rural Africa and part of the disease load may be related to hereditary predisposition, including mutations in the BRCA1 gene. However, the BRCA1 mutations associated with BC in Africa are scarcely characterized. We report here 33 BRCA1 point mutations, among which 2 novel missense variants, found in 59 Central Sudanese premenopausal BC...
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