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Mutations in BRCA-related breast and ovarian cancer in the South African Indian population: A descriptive study.

Cancer genetics - 1 Nov 2021

Combrink Herkulaas Mve, Oosthuizen Jaco, Visser Botma, Chabilal Namitha, Buccimazza Ines, Foulkes William D, van der Merwe Nerina C

Abstract excerpt

Knowledge of the genetic landscape of a specific population group is vital for population-specific diagnosis and treatment of familial breast cancer. Although BRCA-related diagnostic testing has long been implemented in South Africa, the genotyping approach previously failed for the SA Indian population as it was based on other SA population groups. Because this population is uniquely admixed, the lack of...

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PMID: 34218100
DOI: 10.1016/j.cancergen.2021.06.002

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