Article

Environmentally sensitive hotspots in the methylome of the early human embryo

2019-09-23

Abstract excerpt

In humans, DNA methylation marks inherited from gametes are largely erased following fertilisation, prior to construction of the embryonic methylome. Exploiting a natural experiment of seasonal variation including changes in diet and nutritional status in rural Gambia, we analysed two independent child cohorts and identified 259 CpGs showing consistent associations between season of conception (SoC) and DNA methyl...

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Literature Corpus work: 38d72fbc-4eca-5ab4-906f-52c844f1d377
DOI: 10.1101/777508

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