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Involvement of N-6 Adenine-Specific DNA Methyltransferase 1 ( <i>N6AMT1</i> ) in Arsenic Biomethylation and Its Role in Arsenic-Induced Toxicity

30 Dec 2010

Abstract excerpt

BACKGROUND: In humans, inorganic arsenic (iAs) is metabolized to methylated arsenical species in a multistep process mainly mediated by arsenic (+3 oxidation state) methyltransferase (AS3MT). Among these metabolites is monomethylarsonous acid (MMAIII), the most toxic arsenic species. A recent study in As3mt-knockout mice suggests that unidentified methyltransferases could be involved in alternative iAs...

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PMID: 21193388
DOI: 10.1289/ehp.1002733

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