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Article

Hypoxia-inducible factor independent down-regulation of thioredoxin-interacting protein in hypoxia.

FEBS letters - 4 Feb 2011

Chai Tin Fan, Leck Yee Chin, He Hongpeng, Yu Fa-Xing, Luo Yan, Hagen Thilo

Abstract excerpt

Thioredoxin-Interacting Protein (Txnip) is an important regulator of glucose metabolism and functions by inhibiting cellular glucose uptake. The expression of the Txnip gene is sensitive to glucose availability and is negatively correlated with the glycolytic rate. Here we show that hypoxia induces a rapid decrease in Txnip mRNA and protein expression in a Hypoxia-Inducible Factor independent manner. Hypoxia...

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Source

Identifiers

PMID: 21192937
DOI: 10.1016/j.febslet.2010.12.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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