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Article

Rewiring of PDZ domain-ligand interaction network contributed to eukaryotic evolution.

PLoS genetics - 1 Feb 2012

Kim Jinho, Kim Inhae, Yang Jae-Seong, Shin Young-Eun, Hwang Jihye, Park Solip, Choi Yoon Sup, Kim Sanguk

Abstract excerpt

PDZ domain-mediated interactions have greatly expanded during metazoan evolution, becoming important for controlling signal flow via the assembly of multiple signaling components. The evolutionary history of PDZ domain-mediated interactions has never been explored at the molecular level. It is of...

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Identifiers

PMID: 22346764
DOI: 10.1371/journal.pgen.1002510
PMCID: PMC3276551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22346764-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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