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Breaking Barriers. New Insights into Airway Epithelial Barrier Function in Health and Disease

1 May 2014

Abstract excerpt

Epithelial permeability is a hallmark of mucosal inflammation, but the molecular mechanisms involved remain poorly understood. A key component of the epithelial barrier is the apical junctional complex that forms between neighboring cells. Apical junctional complexes are made of tight junctions and adherens junctions and link to the cellular cytoskeleton via numerous adaptor proteins. Although the existence of...

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PMID: 24467704
DOI: 10.1165/rcmb.2013-0541rt

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