Article
Transforming growth factor alpha expression as a response of murine motor neurons to axonal injury and mutation-induced degeneration.
Journal of neuropathology and experimental neurology - 1 May 1997
Lisovoski F, Blot S, Lacombe C, Bellier J P, Dreyfus P A, Junier M P
Abstract excerpt
We previously showed that degenerating adult motor neurons of the murine mutant wobbler, a model of spinal muscular atrophy, express Transforming Growth Factor alpha (TGF alpha), a growth factor endowed with glio- and neurotrophic activities. Here, we evaluated whether TGF alpha expression is a g...
Topics
- Animals
- Axons
- Denervation
- Hypoglossal Nerve
- Hypoglossal Nerve Injuries
- Male
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Motor Neurons
- Muscles
- Mutation
- Nerve Crush
- Nerve Degeneration
- Protein Precursors
- RNA, Messenger
- Spinal Cord
- Transforming Growth Factor alpha