Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 May 2018

Nakashima Hideyuki, Tsujimura Keita, Irie Koichiro, Ishizu Masataka, Pan Miao, Kameda Tomonori, Nakashima Kinichi

Abstract excerpt

Functional neuronal connectivity requires proper neuronal morphogenesis and its dysregulation causes neurodevelopmental diseases. Transforming growth factor-β (TGF-β) family cytokines play pivotal roles in development, but little is known about their contribution to morphological development of neurons. Here we show that the Smad-dependent canonical signaling of TGF-β family cytokines negatively regulates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Dendrites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hippocampus

Share to Intercellular Signaling Peptides and Proteins

Share to Morphogenesis

Share to Nervous System Diseases

Share to Neural Stem Cells

Share to Smad4 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 29695415
DOI: 10.1523/JNEUROSCI.2423-17.2018
PMCID: PMC6596019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression.PMID 29695415Read ↗

Smad4 and Trim33/Tif1γ redundantly regulate neural stem cells in the developing cortex.Semantic proximity Read ↗

Differentiation plasticity regulated by TGF-β family proteins in development and diseaseSemantic proximity Read ↗

Expression pattern of TG-interacting factor 2 during mouse development.Semantic proximity Read ↗

TGF-β Signaling in DevelopmentSemantic proximity Read ↗

Genetic Analysis of the Mammalian Transforming Growth Factor-β SuperfamilySemantic proximity Read ↗

TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric DiseasesSemantic proximity Read ↗

Transforming Growth Factor-&#946; Signaling in Motor Neuron DiseasesSemantic proximity Read ↗

The Xenopus Tgfbi is required for embryogenesis through regulation of canonical Wnt signalling.Semantic proximity Read ↗

The expression of twisted gastrulation in postnatal mouse brain and functional implications.Semantic proximity Read ↗

TGF-beta signals regulate axonal development through distinct Smad-independent mechanisms.Semantic proximity Read ↗

CTGF mediates Smad-dependent transforming growth factor β signaling to regulate mesenchymal cell proliferation during palate development.Semantic proximity Read ↗

The TGFβ intracellular effector Smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cordSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.