Article
Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter.
PloS one - 20 Dec 2010
Fleming Nicholas I, Knower Kevin C, Lazarus Kyren A, Fuller Peter J, Simpson Evan R, Clyne Colin D
Abstract excerpt
BACKGROUND: Granulosa cell tumors (GCT) of the ovary often express aromatase and synthesize estrogen, which in turn may influence their progression. Recently a specific point mutation (C134W) in the FOXL2 protein was identified in >94% of adult-type GCT and it is likely to contribute to their development. A number of genes are known to be regulated by FOXL2, including aromatase/CYP19A1, but it is unclear which...
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