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Article

The impact of genetic susceptibility to systemic lupus erythematosus on placental malaria in mice.

PloS one - 1 Jan 2013

Waisberg Michael, Lin Christina K, Huang Chiung-Yu, Pena Mirna, Orandle Marlene, Bolland Silvia, Pierce Susan K

Abstract excerpt

Severe malaria, including cerebral malaria (CM) and placental malaria (PM), have been recognized to have many of the features of uncontrolled inflammation. We recently showed that in mice genetic susceptibility to the lethal inflammatory autoimmune disease, systemic lupus erythematosus (SLE), conferred resistance to CM. Protection appeared to be mediated by immune mechanisms that allowed SLE-prone mice, prior to...

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Identifiers

PMID: 23675429
DOI: 10.1371/journal.pone.0062820
PMCID: PMC3651086

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