Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2006

Mehrad Borna, Park Stacy J, Akangire Gangaram, Standiford Theodore J, Wu Tianfu, Zhu Jiankun, Mohan Chandra

Abstract excerpt

The genetic predisposition to many autoimmune diseases is inherited as a polygenic trait. It is conceivable that some of the causative alleles in these diseases became prevalent in the population by conferring a survival benefit against environmental assaults, such as infections. We used mice cogenic for genetic loci predisposing to systemic lupus erythomatosus to test the hypothesis that some of these genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adjuvants, Immunologic
Share to Apoptosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Klebsiella pneumoniae

Share to Lupus Erythematosus, Systemic

Share to Mice, Congenic

Share to Mice, Inbred NZB

Share to Neutrophils

Share to Pneumonia, Bacterial

Source

Identifiers

PMID: 16493084
DOI: 10.4049/jimmunol.176.5.3233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections.PMID 16493084Read ↗

Cytokine Dysregulation Induced by Apoptotic Cells Is a Shared Characteristic of Murine LupusSemantic proximity Read ↗

Genetic interactions between susceptibility loci reveal epistatic pathogenic networks in murine lupus.Semantic proximity Read ↗

Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cells.Semantic proximity Read ↗

The lupus susceptibility locus Sle3 is not sufficient to accelerate atherosclerosis in lupus-susceptible low density lipoprotein receptor-deficient mice.Semantic proximity Read ↗

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.Semantic proximity Read ↗

Genetic Dissection of SLESemantic proximity Read ↗

Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strainsSemantic proximity Read ↗

Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in miceSemantic proximity Read ↗

Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death.Semantic proximity Read ↗

<i> FAS <sup>lpr</sup> </i> gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupusSemantic proximity Read ↗

A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice.Semantic proximity Read ↗

The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.