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Article

Phenotypic drift and clonal variation in differentiation antigen expression on AKR T-cell lymphoma lines grown in vitro.

Natural immunity and cell growth regulation - 1 Jan 2000

Howell A L, Richie E R

Abstract excerpt

AKR T-cell lymphomas were adapted to tissue culture and analyzed for reactivity with monoclonal antibodies against Thy-1, Ly-1, Ly-2, Ly-5, and H-2K differentiation antigens to determine whether the original phenotype was maintained after adaptation to in vitro culture. Ly-1 and Ly-2 antigens were lost on the majority of lymphomas early in culture and the expression of other lymphocyte differentiation antigens...

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PMID: 6150437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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