Article
Prevalence of PALB2 mutations in Australasian multiple-case breast cancer families.
Breast cancer research : BCR - 28 Feb 2013
Teo Zhi L, Park Daniel J, Provenzano Elena, Chatfield Catherine A, Odefrey Fabrice A, Nguyen-Dumont Tu, Dowty James G, Hopper John L, Winship Ingrid, Goldgar David E, Southey Melissa C
Abstract excerpt
INTRODUCTION: Population-based studies of breast cancer have estimated that some PALB2 mutations confer a breast cancer risk (penetrance) comparable to the average pathogenic mutation in BRCA2. As this risk is of clinical relevance, we sought to identify mono-allelic PALB2 mutations and determine their frequencies in multiple-case breast cancer families attending Familial Cancer Clinics in Australia and New...
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