Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenomics of human ABC transporter ABCC11 (MRP8): potential risk of breast cancer and chemotherapy failure.

Anti-cancer agents in medicinal chemistry - 1 Oct 2010

Toyoda Yu, Ishikawa Toshihisa

Abstract excerpt

Some genetic polymorphisms of human ABC transporter genes are reportedly related to the risk of certain diseases and patients' responses to medication. Human ABCC11 functions as an ATP-dependent efflux pump for amphipathic anions. One non-synonymous SNP 538G>A (Gly180Arg) has been found to greatly affect the function and stability of de novo synthesized ABCC11 (Arg180) variant protein. The SNP variant lacking...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Drug Resistance, Neoplasm

Share to Pharmacogenetics

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Share to Treatment Failure

Source

Open in PubMed Open full text

Identifiers

PMID: 21182469
DOI: 10.2174/187152010794473975
PMCID: PMC3319924

Genes

ABCC11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenomics of human ABC transporter ABCC11 (MRP8): potential risk of breast cancer and chemotherapy failure.PMID 21182469Read ↗

Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretionSemantic proximity Read ↗

Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor.Semantic proximity Read ↗

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.Semantic proximity Read ↗

Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human ABCC11 Gene: Clinical Practice and Basic Scientific Evidence.Semantic proximity Read ↗

A functional ABCC11 allele is essential in the biochemical formation of human axillary odor.Semantic proximity Read ↗

Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?Semantic proximity Read ↗

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.Semantic proximity Read ↗

The effect of ABCB1 polymorphisms on the outcome of breast cancer treatmentSemantic proximity Read ↗

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.Semantic proximity Read ↗

Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application.Semantic proximity Read ↗

Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.Semantic proximity Read ↗

Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.