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Article

A functional ABCC11 allele is essential in the biochemical formation of human axillary odor.

The Journal of investigative dermatology - 1 Feb 2010

Martin Annette, Saathoff Matthias, Kuhn Fabian, Max Heiner, Terstegen Lara, Natsch Andreas

Abstract excerpt

The characteristic human axillary odor is formed by bacterial action on odor precursors that originate from apocrine sweat glands. Caucasians and Africans possess a strong axillary odor ,whereas many Asians have only a faint acidic odor. In this study, we provide evidence that the gene ABCC11 (MRP8), which encodes an apical efflux pump, is crucial for the formation of the characteristic axillary odor and that a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19710689
DOI: 10.1038/jid.2009.254

Genes

ABCC11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional ABCC11 allele is essential in the biochemical formation of human axillary odor.PMID 19710689Read ↗

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A missense variant of the ABCC11 gene is associated with Axillary Osmidrosis susceptibility and clinical phenotypes in the Chinese Han Population.Semantic proximity Read ↗

Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis.Semantic proximity Read ↗

From Allelic Heterogeneity to Biomechanical Phenotypes: A Functional New Genomic Model of ABCC11 Polymorphisms and Their Role in Human Chemical EcologySemantic proximity Read ↗

Correlation of axillary osmidrosis to a SNP in the ABCC11 gene determined by the Smart Amplification Process (SmartAmp) method.Semantic proximity Read ↗

A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene.Semantic proximity Read ↗

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The specific biochemistry of human axilla odour formation viewed in an evolutionary contextSemantic proximity Read ↗

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