Article
Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation.
PloS one - 14 Dec 2010
Mewborn Stephanie K, Puckelwartz Megan J, Abuisneineh Fida, Fahrenbach John P, Zhang Yuan, MacLeod Heather, Dellefave Lisa, Pytel Peter, Selig Sara, Labno Christine M, Reddy Karen, Singh Harinder, McNally Elizabeth
Abstract excerpt
BACKGROUND: Lamins A and C, encoded by the LMNA gene, are filamentous proteins that form the core scaffold of the nuclear lamina. Dominant LMNA gene mutations cause multiple human diseases including cardiac and skeletal myopathies. The nuclear lamina is thought to regulate gene expression by its direct interaction with chromatin. LMNA gene mutations may mediate disease by disrupting normal gene expression....
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