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Article

Integrated analysis reveals the alterations that LMNA interacts with euchromatin in LMNA mutation-associated dilated cardiomyopathy.

Clinical epigenetics - 6 Jan 2021

Zhang Xiaolin, Shao Xiuli, Zhang Ruijia, Zhu Rongli, Feng Rui

Abstract excerpt

BACKGROUND: Dilated cardiomyopathy (DCM) is a serious cardiac heterogeneous pathological disease, which may be caused by mutations in the LMNA gene. Lamins interact with not only lamina-associated domains (LADs) but also euchromatin by alone or associates with the lamina-associated polypeptide 2 alpha (LAP2α). Numerous studies have documented that LMNA regulates gene expression by interacting with LADs in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33407844
DOI: 10.1186/s13148-020-00996-1
PMCID: PMC7788725

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