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Dysregulated APP expression and α-secretase processing of APP is involved in manganese-induced cognitive impairment

28 May 2021

Abstract excerpt

Excessive exposure to manganese (Mn) can cause cognitive impairment, a common feature of Alzheimer's disease (AD), but the mechanisms remain unclear. Amyloid precursor protein (APP) is key to AD pathogenesis, and whether APP and its secretase processing are involved in Mn-induced cognitive impairment remains unknown. In the present study, we established a model of Mn-induced neurotoxicity in vivo (male C57BL/6,...

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PMID: 34058678
DOI: 10.1016/j.ecoenv.2021.112365

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