The Wiskott–Aldrich syndrome

Abstract excerpt

The biological mechanisms responsible for the pathophysiology of the Wiskott–Aldrich syndrome (WAS) have been shown to be linked to the regulation of actin polymerization in haematopoietic cells. WAS protein (WASp) is now known to be a member of a unique family sharing similar domain structures, which are responsible for transduction of signals from the cell membrane to the actin cytoskeleton. The interaction...

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