Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.

Pharmacogenetics and genomics - 1 Aug 2005

Zhang Zhengdong, Shi Qiuling, Sturgis Erich M, Spitz Margaret R, Wei Qingyi

Abstract excerpt

Low dietary intake of fruits and vegetables, particularly folate deficiency, has been associated with the risk of squamous cell carcinoma of the head and neck (SCCHN). We hypothesized that polymorphisms of the cytosolic serine hydroxymethyltransferase (SHMT1) gene involved in folate-dependent, one-carbon metabolism are associated with SCCHN risk. In a hospital-based, case-control study of 721 non-Hispanic white...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Glycine Hydroxymethyltransferase

Share to Haplotypes

Share to Head and Neck Neoplasms

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Source

Identifiers

PMID: 16006999
DOI: 10.1097/01.fpc.0000170915.19522.b2

Genes

SHMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.PMID 16006999Read ↗

Polymorphisms of cytosolic serine hydroxymethyltransferase and risk of lung cancer: a case-control analysis.Semantic proximity Read ↗

Association between cytosolic serine hydroxymethyltransferase (SHMT1) gene polymorphism and cancer risk: a meta-analysis.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis.Semantic proximity Read ↗

Polymorphism of cytosolic serine hydroxymethyltransferase and breast cancer risk: evidence from a meta-analysis.Semantic proximity Read ↗

Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.Semantic proximity Read ↗

One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study.Semantic proximity Read ↗

A meta-analysis of the C1420T polymorphism in cytosolic serine hydroxymethyltransferase (SHMT1) among Caucasian colorectal cancer populations.Semantic proximity Read ↗

Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis.Semantic proximity Read ↗

[Correlations between serine hydroxymethyltransferase1 C1420T polymorphisms and susceptibilities to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma].Semantic proximity Read ↗

SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients.Semantic proximity Read ↗

A SHMT1 variant decreases the risk of nonsyndromic cleft lip with or without cleft palate in Chile.Semantic proximity Read ↗

C1420T polymorphism of cytosolic serine hydroxymethyltransferase and risk of cancer: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.