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Article

Polymorphisms of cytosolic serine hydroxymethyltransferase and risk of lung cancer: a case-control analysis.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2007

Wang Luo, Lu Jiachun, An Jiaze, Shi Qiuling, Spitz Margaret R, Wei Qingyi

Abstract excerpt

Suboptimal DNA repair capacity is a risk factor for cancer that may be modulated by dietary nutrient intake, and serine hydroxymethyltransferase (SHMT) participates in folate metabolism and synthesis of purines and pyrimidines needed for DNA repair. Therefore, we tested our hypothesis that genetic variants of the cytosolic SHMT (SHMT1) gene are associated with lung cancer risk. In a hospital-based case-control...

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Identifiers

PMID: 17420066
DOI: 10.1016/j.lungcan.2007.03.002
PMCID: PMC2693017

Genes

SHMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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