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Genetic variants in hormone-related genes and risk of breast cancer.

PloS one - 1 Jan 2013

Clendenen Tess, Zeleniuch-Jacquotte Anne, Wirgin Isaac, Koenig Karen L, Afanasyeva Yelena, Lundin Eva, Arslan Alan A, Axelsson Tomas, Försti Asta, Hallmans Göran, Hemminki Kari, Lenner Per, Roy Nirmal, Shore Roy E, Chen Yu

Abstract excerpt

Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between...

Topics

Adult
Aged
Breast Neoplasms
Demography
Female
Genetic Predisposition to Disease
Genetic Variation
Hormones
Humans
Life Style
Menopause

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Risk Factors

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Open in PubMed Open full text

Identifiers

PMID: 23935996
DOI: 10.1371/journal.pone.0069367
PMCID: PMC3720532

Genes

ESR1
PGR
SHBG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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