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Article

Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.

Oncotarget - 28 Mar 2017

Kuo Sung-Hsin, Yang Shi-Yi, You San-Lin, Lien Huang-Chun, Lin Ching-Hung, Lin Po-Han, Huang Chiun-Sheng

Abstract excerpt

In this study, we investigated whether single nucleotide polymorphisms (SNPs) identified by genome-wide association study (GWAS) (MAP3K1, FGFR2, TNRC9, HCN1, and 5p12), and SNPs involved in the metabolism of estrogen (CYP19, COMT, ESR1, and UGT1A1), tamoxifen (CYP2C9, CYP2C19, CYP3A5, and CYP2D6), and chemotherapeutic agents (ABCB1, ALDH3A1, and CYP2B6) are associated with the prognoses of 414 hormone receptor...

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Topics

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Share to Adenocarcinoma, Mucinous
Share to Carcinoma, Ductal, Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Lobular

Share to Carcinoma, Medullary

Share to Cytochrome P-450 CYP2B6

Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Share to MAP Kinase Kinase Kinase 1

Share to Neoplasms, Hormone-Dependent

Source

Open in PubMed Open full text

Identifiers

PMID: 28178648
DOI: 10.18632/oncotarget.14995
PMCID: PMC5400556

Genes

ESR1
HCN1
ABCB1
COMT
FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.PMID 28178648Read ↗

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