Low blood glucose precipitates spike-and-wave activity in genetically predisposed animals.

Abstract excerpt

PURPOSE: Absence epilepsies are common, with a major genetic contribution to etiology. Certain environmental factors can influence absence occurrence but a complete understanding of absence precipitation is lacking. Herein we investigate if lowering blood glucose increases spike-wave activity in mouse models with varying seizure susceptibility. METHODS: Three mouse models were used: an absence seizure model based...

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