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Article

Enhanced mutability at the tk locus in the radiosensitive double-strand break repair mutant xrs5.

Mutation research - 1 Aug 1990

Mussa T A, Singh B, Bryant P E

Abstract excerpt

The thymidine kinase locus (tk) has been utilised as the target locus to measure the induced mutation frequency following X-irradiation in the X-ray-sensitive xrs5 mutant and its parent CHO K1 line of Chinese hamster cells. Mutations to tk- cells were measured by plating cells in selective medium containing trifluorothymidine after a post-irradiation expression time of 4 days. Our results show that the mutation...

Topics

Animals
Cell Line
Cell Survival
Chromosomes
Cricetinae
DNA Damage
DNA Repair
Dose-Response Relationship, Radiation
Mutation
Thymidine Kinase
Trifluridine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2117250
DOI: 10.1016/0027-5107(90)90025-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2117250-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Enhanced mutability at the tk locus in the radiosensitive double-strand break repair mutant xrs5.PMID 2117250Read ↗

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