Article
Association between interleukin-3 gene polymorphism and acute rejection after kidney transplantation.
Transplantation proceedings - 1 Dec 2010
Lee D-Y, Song S-B, Moon J-Y, Jeong K-H, Park S J, Kim H-J, Kang S W, Lee S-H, Kim Y-H, Chung J-H, Ihm C-G, Lee T-W
Abstract excerpt
BACKGROUND: Acute rejection (AR) after kidney transplantation resulting from alloimmune responses has a negative effect on graft survival. AR is mainly caused by T-cell immune responses activated by cytokines, including interleukin (IL)-2, -4, and -7. Many reports have shown that single nucleotide polymorphisms (SNPs) of these cytokines can affect the occurrence of AR. IL-3, which is secreted by activated T...
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