Article
Association of G-137C IL-18 promoter polymorphism with acute allograft rejection in renal transplant recipients.
Transplantation - 15 Dec 2008
Kim Chan-Duck, Ryu Hye-Myung, Choi Ji-Young, Choi Hee-Jeong, Choi Hyuk-Joon, Cho Ji-Hyung, Park Sun-Hee, Won Dong-Il, Kim Yong-Lim
Abstract excerpt
BACKGROUND: Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is postulated to play a role in mechanism of renal allograft rejection and strongly induces interferon (IFN)-gamma production. The aim of this study was to investigate the association of the G-137C IL-18 promoter polymorphism with acute allograft rejection in renal transplant recipients (RTRs). METHODS: A total of 226 RTRs and 148...
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