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Article

Novel staining pattern of p53 in Barrett’s dysplasia – the absent pattern

1 Dec 2010

Abstract excerpt

Sir: Barrett’s oesophagus (BO) is conversion of oesophageal squamous mucosa to a glandular phenotype, and is a consequence of gastro-oesophageal reflux. This is a precursor to oesophageal adenocarcinoma (OA), which is rising rapidly in western countries and carries a poor prognosis.1 This pathway is characterized by intestinal metaplasia and increasing grades of dysplasia before cancer supervenes. Recognizing...

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PMID: 21166706
DOI: 10.1111/j.1365-2559.2010.03715.x

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