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Article

New genes in Drosophila quickly become essential.

Science (New York, N.Y.) - 17 Dec 2010

Chen Sidi, Zhang Yong E, Long Manyuan

Abstract excerpt

To investigate the origin and evolution of essential genes, we identified and phenotyped 195 young protein-coding genes, which originated 3 to 35 million years ago in Drosophila. Knocking down expression with RNA interference showed that 30% of newly arisen genes are essential for viability. The proportion of genes that are essential is similar in every evolutionary age group that we examined. Under constitutive...

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Identifiers

PMID: 21164016
DOI: 10.1126/science.1196380
PMCID: PMC7211344

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