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Article

The complex relationship of gene duplication and essentiality.

Trends in genetics : TIG - 1 Apr 2009

Makino Takashi, Hokamp Karsten, McLysaght Aoife

Abstract excerpt

In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons. We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were...

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PMID: 19285746
DOI: 10.1016/j.tig.2009.03.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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