Article
Modulation of the cell-mediated immune function by interferon alpha, beta or gamma can partially reverse the immunosuppression induced by human T-cell leukemia virus I in human cord blood cultures.
Cancer immunology, immunotherapy : CII - 1 Jan 1990
D'Onofrio C, Pesce C D, Fontana T, Ciprani F, Bonmassar E, Caliŏ R
Abstract excerpt
Infection with human T-cell leukemia virus type I (HTLV-I) is associated in vitro and in vivo with a remarkable depression of cell-mediated immune functions. In the present report it is shown that early events following virus-induced suppression of the cell-mediated immune response of freshly isolated cord blood mononuclear cells (CBL) infected with HTLV-I can be partially counteracted by treatment with...
Topics
- Cell Division
- Clone Cells
- Fetal Blood
- HTLV-I Infections
- Human T-lymphotropic virus 1
- Humans
- Immune Tolerance
- Immunity, Cellular
- Interferon Type I
- Interferon-gamma