Article
Inhibition of lymphocyte blastogenic response in healthy donors treated with recombinant human granulocyte colony-stimulating factor (rhG-CSF): possible role of lactoferrin and interleukin-1 receptor antagonist.
Bone marrow transplantation - 1 Sept 1997
Rutella S, Rumi C, Testa U, Sica S, Teofili L, Martucci R, Peschle C, Leone G
Abstract excerpt
The effects of rhG-CSF on lymphocyte blastogenesis were evaluated in six healthy donors, submitted to progenitor cell mobilization for allogeneic transplantation. Neutrophil, monocyte and lymphocyte count increased 6.7-fold, 5.3-fold and 2.0-fold on day +4 of rhG-CSF as compared with baseline. Th...
Topics
- Adult
- Antigens, CD
- Female
- Granulocyte Colony-Stimulating Factor
- HLA-DR Antigens
- Humans
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-10
- Interleukin-8
- Lactoferrin
- Leukocytes, Mononuclear
- Lymphocyte Activation
- Male