Article
Characterization of the alloreactivity and anti-leukemia reactivity of cord blood mononuclear cells.
Bone marrow transplantation - 1 Mar 1995
Keever C A, Abu-Hajir M, Graf W, McFadden P, Prichard P, O'Brien J, Flomenberg N
Abstract excerpt
It has been suggested that cord blood T cells may be less able to mediate GVHD than marrow-derived T cells due to their naive status. A decreased potential for GVHD may be advantageous for allogeneic transplant, but this benefit might be counteracted by loss of the GVHD associated graft-versus-leukemia (GVL) effect. The GVL potential of cord blood could be doubly compromised since cord blood NK cell activity is...
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