Article
Defolliculated (dfl): a dominant mouse mutation leading to poor sebaceous gland differentiation and total elimination of pelage follicles.
The Journal of investigative dermatology - 1 Jul 2002
Porter Rebecca M, Jahoda Colin A B, Lunny Declan P, Henderson Gayle, Ross Jane, McLean W H Irwin, Whittock Neil V, Wilson Neil J, Reichelt Julia, Magin Thomas M, Lane E Birgitte
Abstract excerpt
Defolliculated is a novel spontaneous mouse mutation that maps to chromosome 11 close to the type I keratin locus. Histology shows abnormal differentiation of the sebaceous gland, with the sebocytes producing little or no sebum and undergoing abnormal cornification. The hair follicles fail to regress during catagen leading to abnormally long follicles. In contrast the hair shafts are shorter than normal,...
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