Article
dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration.
Cell stem cell - 6 Aug 2015
Nelson Amanda M, Reddy Sashank K, Ratliff Tabetha S, Hossain M Zulfiquer, Katseff Adiya S, Zhu Amadeus S, Chang Emily, Resnik Sydney R, Page Carly, Kim Dongwon, Whittam Alexander J, Miller Lloyd S, Garza Luis A
Abstract excerpt
Regeneration of skin and hair follicles after wounding--a process known as wound-induced hair neogenesis (WIHN)--is a rare example of adult organogenesis in mammals. As such, WIHN provides a unique model system for deciphering mechanisms underlying mammalian regeneration. Here, we show that dsRNA, which is released from damaged skin, activates Toll-Like Receptor 3 (TLR3) and its downstream effectors IL-6 and...
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