Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Dec 2010

Sheline Yvette I, Morris John C, Snyder Abraham Z, Price Joseph L, Yan Zhizi, D'Angelo Gina, Liu Collin, Dixit Sachin, Benzinger Tammie, Fagan Anne, Goate Alison, Mintun Mark A

Abstract excerpt

Identifying high-risk populations is an important component of disease prevention strategies. One approach for identifying at-risk populations for Alzheimer's disease (AD) is examining neuroimaging parameters that differ between patients, including functional connections known to be disrupted wit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aniline Compounds
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Brain Mapping

Share to Neural Pathways

Share to Plaque, Amyloid

Share to Positron-Emission Tomography

Share to Thiazoles

Source

Open in PubMed Open full text

Identifiers

PMID: 21159973
DOI: 10.1523/JNEUROSCI.3987-10.2010
PMCID: PMC3023180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21159973-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42.PMID 21159973Read ↗

Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers.Semantic proximity Read ↗

Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation.Semantic proximity Read ↗

APOE ε 4 and resting‐state functional connectivity in racially/ethnically diverse older adultsSemantic proximity Read ↗

Precuneus degeneration in nondemented elderly individuals with APOE ɛ4: Evidence from structural and functional MRI analyses.Semantic proximity Read ↗

Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP, presenilins and APOE ε4.Semantic proximity Read ↗

The effects of APOEe4 allele on cerebral structure, function, and related interactions with cognition in young adults.Semantic proximity Read ↗

Resting-state functional dynamics alterations relate to plasma amyloid markers and explain memory impairments in the TgF344-AD model of Alzheimer’s diseaseSemantic proximity Read ↗

ApoE ε4 Allele Related Alterations in Hippocampal Connectivity in Early Alzheimer's Disease Support Memory Performance.Semantic proximity Read ↗

Gender modulates the APOE ε4 effect in healthy older adults: convergent evidence from functional brain connectivity and spinal fluid tau levels.Semantic proximity Read ↗

The effects of APOE on the functional architecture of the resting brain.Semantic proximity Read ↗

Altered small-world anatomical networks in Apolipoprotein-E4 (ApoE4) carriers using MRI.Semantic proximity Read ↗

Modulation on brain gray matter activity and white matter integrity by APOE ε4 risk gene in cognitively intact elderly: A multimodal neuroimaging study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.