Article
Perspectives for tailored chemoprevention and treatment of colorectal cancer in Lynch syndrome.
Critical reviews in oncology/hematology - 1 Nov 2011
Heijink Dianne M, de Vries Elisabeth G E, Koornstra Jan J, Hospers Geke A P, Hofstra Robert M W, van Vugt Marcel A T M, de Jong Steven, Kleibeuker Jan H
Abstract excerpt
Lynch syndrome (LS) is caused by a germline mutation in one of the mismatch repair (MMR) genes. The resulting loss of MMR gene function induces a strong mutator phenotype and predisposition to colorectal cancer (CRC). LS mutation carriers undergo regular colonoscopic surveillance and have extensive colonic resection in case of cancer because of the chance of metachronous tumors. Given the high risk and early...
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