Cancer risk in Lynch Syndrome.

Abstract excerpt

Lynch Syndrome, or hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by inactivating mutations in DNA mismatch repair genes. It accounts for 2-4 % of all incident colorectal cancers. Mutation carriers are at risk of early onset colorectal cancer, endometrial cancer, and a spectrum of other tumours. Accurate estimation of cancer risk for mutation...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Colorectal Cancer Screening and Detection
• Share to Colorectal Neoplasms, Hereditary Nonpolyposis
• Share to Genetic factors in colorectal cancer